Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition
Ioannis Akoumianakis, Ileana Badi, Gillian Douglas, Surawee Chuaiphichai, L Herdman, Nadia Akawi, Marios Margaritis, Alexios S. Antonopoulos, Evangelos K. Oikonomou, Costas Psarros, Nikolaos Galiatsatos, Dimitris Tousoulis, Attila Kardos, Rana Sayeed, George Krasopoulos, Mario Petrou, Uwe Schwahn, Paulus Wohlfart, Norbert Tennagels, Keith M. Channon, Charalambos Antoniades
Abstract
mice treated with DPP4i. High plasma DPP4 activity and high insulin were additively related with higher cardiac mortality in patients with coronary atherosclerosis undergoing CABG. These findings may explain the inability of aggressive insulin treatment to improve cardiovascular outcomes, raising the question whether vascular insulin sensitization with DPP4i should precede initiation of insulin treatment and continue as part of a long-term combination therapy.