Stereoselective Preparation of CF<sub>3</sub>-Containing Cyclopropanes
Veronika Myronova, Dominique Cahard, Ilan Marek
Abstract
A regio- and diastereoselective carbometalation of easily accessible CF3-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF3 group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl rings possessing two adjacent quaternary carbon stereocenters with excellent diastereoselectivities.
Topics & Concepts
StereocenterChemistryStereoselectivityCombinatorial chemistryQuaternary carbonStereochemistryOrganic chemistryCatalysisEnantioselective synthesisCyclopropane Reaction MechanismsFluorine in Organic ChemistryN-Heterocyclic Carbenes in Organic and Inorganic Chemistry