Malachite green: a long-buried water-soluble AIEgen with near-infrared fluorescence for living cell nucleus staining
Yuan Luo, Lihua Zhou, Lili Du, Yangzi Xie, Xiang-Yang Lou, Lintao Cai, Ben Zhong Tang, Ping Gong, Pengfei Zhang
Abstract
Fluorescent imaging probes are crucial for exploring nucleus-related cellular events in live cells. Ideal probes should be photostable, small-sized, highly contrasted, and low in background. Here, we discovered that malachite green is a water-soluble near-infrared luminogen with aggregation-induced emission properties. Importantly, it can be used for living cell nucleus staining in a wash-free manner.
Topics & Concepts
Malachite greenNucleusFluorescenceStainingBiophysicsInfraredChemistryCellLive cell imagingPhotochemistryCell biologyBiochemistryBiologyOpticsOrganic chemistryPhysicsAdsorptionGeneticsLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsPhotoreceptor and optogenetics research