Anticancer Potential of Compounds Bearing Thiazolidin-4-one Scaffold: Comprehensive Review
Dalbir Singh, Mona Piplani, Harsha Kharkwal, Sankaranarayanan Murugesan, Yogendra Singh, A.K. Aggarwal, Subhash Chander
Abstract
Thiazolidin-4-ones is a versatile and privileged nucleus comprising of a five five-membered heterocyclic ring system possessing sulphur heteroatom and a cyclic amide bond. Extensive research and review studies mainly published in the last decade explored the diverse types of biological activities of this nucleus with potential therapeutic applications. Various silent features like drug likeness behaviour, suitability for diversity-oriented synthesis, and its sensitivity toward the redox tumour m
Topics & Concepts
ScaffoldBearing (navigation)ChemistryComputational biologyComputer scienceBiologyEngineeringBiomedical engineeringArtificial intelligenceSynthesis and biological activitySynthesis of heterocyclic compoundsQuinazolinone synthesis and applications