Synthesis and pharmacological effects of novel benzenesulfonamides carrying benzamide moiety as carbonic anhydrase and acetylcholinesterase inhibitors
Mehtap Tugrak, Halise İnci Gül, Barış Anıl, İlhami Gülçın
Abstract
(Ki = 8.91 ± 1.65 nM, AChE) can be considered as lead compounds of this study with their promising bioactivity results. Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes.
Topics & Concepts
ChemistryBenzamideCarbonic anhydraseAcetylcholinesteraseStereochemistryCarbonic Anhydrase IPharmacophoreMoietyAchéEnzymeSulfonamideProton NMRActive siteBiochemistryEnzyme function and inhibitionCholinesterase and Neurodegenerative DiseasesPhenothiazines and Benzothiazines Synthesis and Activities