Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes
Casey E. Romanoski, Xinshuai Qi, Shreya Sangam, Rebecca Vanderpool, Robert S. Stearman, Austin C. Conklin, Manuel L. Gonzalez‐Garay, Franz Rischard, Ramon J. Ayon, Jian Wang, Tatum S. Simonson, Aleksandra Babicheva, Yinan Shi, Haiyang Tang, Ayako Makino, Yogendra Kanthi, Mark W. Geraci, Joe G. N. Garcia, Jason X.‐J. Yuan, Ankit A. Desai
Abstract
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
Topics & Concepts
MedicineTranscriptomeCandidate genePulmonary hypertensionGeneDiseaseBioinformaticsInternal medicineCardiologyGene expressionGeneticsBiologyPulmonary Hypertension Research and TreatmentsRNA modifications and cancerMicroRNA in disease regulation