Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of <i>Candida</i> Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits
Rūta Petraitienė, Vidmantas Petraitis, Bo Bo Win Maung, Robert S. Mansbach, Michael R. Hodges, Malcolm Finkelman, Karen Joy Shaw, Thomas J. Walsh
Abstract
Candida endophthalmitis is a serious sight-threatening complication of candidemia that may occur before or during antifungal therapy. Hematogenous Candida meningoencephalitis (HCME) is also a serious manifestation of disseminated candidiasis in premature infants, immunosuppressed children, and immunocompromised adults.
Topics & Concepts
EndophthalmitisMeningoencephalitisMycosisComplicationMedicineImmunologySurgeryAntifungal resistance and susceptibilityOcular Infections and TreatmentsBacterial Infections and Vaccines