Choose your leaving group: selective photodeprotection in a mixture of <i>p</i>HP-caged compounds by VIPER excitation
Luuk J. G. W. van Wilderen, Daniela Kern-Michler, Carsten Neumann, Matiss Reinfelds, Jan von Cosel, Maximiliane Horz, Irène Burghardt, Alexander Heckel, Jens Bredenbeck
Abstract
HP is found to be an excellent candidate, as free LG formation is observed to occur with a 10 ps lifetime. The devised strategy may open up new complex uncaging applications, where multiple LGs can be formed locally on a short time scale and in any sequence.
Topics & Concepts
VIPeRChemistryGroup (periodic table)ExcitationViper VenomsOrganic chemistryBiochemistryVenomEngineeringSnake venomEnzymeElectrical engineeringPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchRadical Photochemical Reactions