Hydroxy-directed fluorination of remote unactivated C(sp<sup>3</sup>)–H bonds: a new age of diastereoselective radical fluorination
Stefan Andrew Harry, Michael Richard Xiang, Eric Holt, Andrea Zhu, Fereshte Ghorbani, Dhaval Patel, Thomas Lectka
Abstract
We report a photochemical, hydroxy-directed fluorination that addresses the prevailing challenge of high diastereoselectivity. Numerous motifs showcase a range of regio- and stereochemical outcomes based on the configuration of the hydroxy group.
Topics & Concepts
ChemistryMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods