Dysregulation of MiRNA Expression in Patients With Chronic Myelogenous Leukemia At Diagnosis: A Systematic Review
Mohammad Parsa‐kondelaji, Maryam Musavi, Faezeh Barzegar, Neda Abbasian, Mehrdad Rostami, Mohammad Reza Seyedtaghia, Seyyed Saleh Hashemi, Mahdiyeh Modi, Banafsheh Nikfar, Amir Abbas Momtazi‐Borojeni
Abstract
Aim: The present systematic review aimed to explore miRNAs as a potential biomarker for early diagnosis of chronic myeloid leukemia (CML). Materials & methods: A systematic search was conducted in three electronic databases, including Web of Science, Scopus and PubMed, to obtain relevant articles investigating the alteration of miRNA expression in patients with CML. Results: The authors found miRNAs whose expression changes are effective in the induction of CML disease. Among them, miR-21 and miR-155 were identified as the most common miRNAs with increased expression and miR-150 and miR-146 as the most common miRNAs with decreased expression. Conclusion: miRNAs can be used as an indicator for the early detection and treatment of CML phase.