Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State
Abbye E. McEwen, Seth A. Cohen, Chloe Bryson‐Cahn, Catherine Liu, Steven A. Pergam, John B. Lynch, Adrienne Schippers, Kathy Strand, Estella Whimbey, Nandita S Mani, Allison Zelikoff, Vanessa A Makarewicz, Elizabeth R. Brown, Shah A. Mohamed Bakhash, Noah Baker, Jared Castor, Robert Livingston, Meei‐Li Huang, Keith R. Jerome, Alexander L. Greninger, Pavitra Roychoudhury
Abstract
Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1-23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections (P < .05).
Topics & Concepts
MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakBetacoronavirusRespiratory systemVirologyCoronavirusCoronavirus InfectionsImmunologyInternal medicineOutbreakInfectious disease (medical specialty)DiseaseSARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingVaccine Coverage and Hesitancy