Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and <i>in vivo</i> studies
Mohamed M. Khalifa, Ahmed A. Al‐Karmalawy, Eslam B. Elkaeed, Mohamed S. Nafie, Mohamed A. Tantawy, Ibrahim H. Eissa, Hazem A. Mahdy
Abstract
antitumor examination. It inhibited tumour proliferation reducing solid tumour volume and mass. Additionally, it restored liver enzymes, proteins, and CBC parameters near-normal, indicating a remarkable amelioration in their functions along with histopathological examinations.
Topics & Concepts
PhthalazineChemistryIn vivoIC50Docking (animal)Intercalation (chemistry)In vitroBiochemistryCytotoxicityDNACytotoxic T cellEnzymeStereochemistryPharmacologyBiologyBiotechnologyMedicineOrganic chemistryNursingInorganic chemistryCancer therapeutics and mechanismsSynthesis and Biological EvaluationBiochemical and Molecular Research