Tailored single-lung ventilation approaches and postoperative pulmonary outcomes in thoracic surgery
Yun Sha, Rui Xu, Shihao Shao, Jinyuan Yang, Beining Tang, Qingna Liang, Zhonghui Wang
Abstract
triad" facilitates personalized intraoperative respiratory management by stabilizing alveoli, optimizing V/Q matching, and minimizing oxidative stress, thereby significantly reducing PPCs risk compared to conventional fixed-parameter approaches. Current limitations include insufficient multicenter validation, technical dependency on advanced monitoring/ventilators, and lack of subgroup analyses for high-risk populations. Future research should prioritize multicenter randomized controlled trials to establish universal thresholds for tailored parameters. Integration of artificial intelligence (AI) for real-time respiratory mechanics analysis and multimodal imaging is essential to refine precision thresholds. Ultimately, this strategy aims to establish an evidence-based, precision perioperative ventilation framework that optimizes clinical outcomes in thoracic surgical patients by overcoming the constraints of standardized ventilation protocols.