Discovery of triaromatic flexible agents bearing 1,2,3-Triazole with selective and potent anti-breast cancer activity and CDK9 inhibition supported by molecular dynamics
Saleh Ihmaid, Ateyatallah Aljuhani, Mosa Alsehli, Nadjet Rezki, Ali Alawi, Ahmed Aldhafiri, Samir A. Salama, Hany E. A. Ahmed, Mohamed Reda Aouad
Topics & Concepts
ChemistryStaurosporineDocking (animal)StereochemistryCytotoxicityMTT assayIC50Mechanism of actionIn vitroEnzymeBiochemistryProtein kinase ANursingMedicineClick Chemistry and ApplicationsSynthesis and biological activityComputational Drug Discovery Methods