Construction of Leaderless-Bacteriocin-Producing Bacteriophage Targeting E. coli and Neighboring Gram-Positive Pathogens
Yoshimitsu Masuda, Shun Kawabata, Tatsuya Uedoi, Ken–ichi Honjoh, Takahisa Miyamoto
Abstract
-T7 phage, can control the growth of both the Gram-negative host strain and neighboring Gram-positive bacteria while preventing the emergence of phage resistance in the host strain. There are several different types of LLBs and phages, suggesting that we may be able to design a battery of LLB-phages by selecting novel combinations of LLBs and phages. These constructs could be tailored to control various bacterial contaminations and infectious diseases.
Topics & Concepts
Lytic cycleBacteriophagePhage therapyBiologyMicrobiologyLysinPhagemidEscherichia coliLysogenic cycleBacteriocinPhage displayGenomeGeneBacteriaVirologyAntimicrobialGeneticsVirusAntibodyBacteriophages and microbial interactionsProbiotics and Fermented FoodsBacterial Genetics and Biotechnology