S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy
Zhiqiang Xie, Liqing Lu, Zhenghua Wang, Qinhong Luo, Yuchen Yang, Tian Fang, Ziyi Chen, Dejun Ma, Junmin Quan, Zhen Xi
Topics & Concepts
ProdrugChemistryImmunotherapyCancer immunotherapyDeoxyriboseStimulator of interferon genesStingPharmacologyAgonistCancer researchImmune systemBiochemistryImmunologyNucleic acidInnate immune systemReceptorEngineeringAerospace engineeringBiologyMedicineinterferon and immune responsesRNA modifications and cancerImmune Response and Inflammation