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Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studies

Deepa R. Parmar, Jigar Y. Soni, Ramakrishna Guduru, Rahul H. Rayani, Rakesh V. Kusurkar, Anand Vala, Sahista N. Talukdar, Ibrahim H. Eissa, Ahmed M. Metwaly, Ahmed Khalil, Vishwanath Zunjar, Satyanarayana Battula

2021Bioorganic Chemistry79 citationsDOI

Topics & Concepts

ChemistryAzetidineA431 cellsStereochemistryDocking (animal)Cell cultureDU145In silicoIn vitroCisplatinBiochemistryCancer cellCellCell cycleCancerBiologyLNCaPGeneticsMolecular medicineMedicineChemotherapyNursingGeneSynthesis of β-Lactam CompoundsSynthesis and Catalytic ReactionsClick Chemistry and Applications
Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studies | Litcius