Ribosome-targeting antibiotic control NLRP3-mediated inflammation by inhibiting mitochondrial DNA synthesis
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Topics & Concepts
InflammasomeDoxycyclineGene knockdownBiologyCaspase 1NLRC4MitochondrionAIM2Mitochondrial DNACell biologyTranslation (biology)AntibioticsInflammationMolecular biologyMicrobiologyApoptosisBiochemistryGeneImmunologyMessenger RNAInflammasome and immune disordersinterferon and immune responsesRNA modifications and cancer