Time in Range as a Research Outcome Measure
Joseph G. Timmons, James G. Boyle, John R. Petrie
Abstract
Time in range (TIR) is gaining ground as an outcome measure in type 1 diabetes trials. However, inclusion of TIR raises several issues for trial design. In this article, the authors begin by defining TIR and describing the current international consensus around TIR targets. They then expand on evidence for the validity of TIR as a primary clinical trial outcome before concluding with some practical, ethical, and logistical implications.
Topics & Concepts
MedicineOutcome (game theory)Measure (data warehouse)Clinical trialInclusion (mineral)MEDLINEMedical physicsInternal medicineSocial psychologyData miningPsychologyComputer scienceLawMathematicsMathematical economicsPolitical scienceDiabetes Management and ResearchDiabetes Treatment and ManagementPancreatic function and diabetes