Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues
Nicola Ingram, Laura E. McVeigh, Radwa H. Abou‐Saleh, Juliana Maynard, Sally A. Peyman, James R. McLaughlan, Michael Fairclough, Gemma Marston, Elizabeth M. A. Valleley, Jorge L. Jimenez-Macias, Antonia Charalambous, William A. Townley, Malcolm Haddrick, Antonia Wierzbicki, Alexander Wright, Milène Volpato, Peter B. Simpson, Darren Treanor, Neil H. Thomson, Paul M. Loadman, Richard J. Bushby, Benjamin Johnson, Pamela F. Jones, J A Evans, Steven Freear, Alexander F. Markham, Stephen D. Evans, P. Louise Coletta
Abstract
thMBs provide a generic platform for the targeted, ultrasound-triggered delivery of cytotoxic drugs by enhancing tumor responses to low dose drug delivery via combined effects on circulation, tumor drug accumulation and exposure and altered metabolism in normal tissues.