Coronavirus disease 2019 (COVID-19) in domestic animals and wildlife: advances and prospects in the development of animal models for vaccine and therapeutic research
Khan Sharun, Ruchi Tiwari, Shailesh Kumar Patel, Kumaragurubaran Karthik, Mohd. Iqbal Yatoo, Yashpal Singh Malik, Karam Pal Singh, Parmod Kumar Panwar, Harapan Harapan, Raj Kumar Singh, Kuldeep Dhama
Abstract
docking studies, sequence-based computational studies, and experimental studies have shown the possibility of SARS-CoV-2 infection and transmission in cats, ferrets, and other domestic/wild animals, the results are not conclusive of infection under natural conditions. Identifying the potential host range of SARS-CoV-2 will not only help prevent the possibility of human-to-animal and animal-to-human transmission but also assist in identifying efficient animal models that can mimic the clinical symptoms, transmission potential, and pathogenesis of the disease. Such an efficient animal model will accelerate the process of development and evaluation of vaccines, immunotherapeutics, and other remedies for SARS-CoV-2.