Inhibition of Non-small Cell Lung Cancer by Ferroptosis and Apoptosis Induction through P53 and GSK-3β/Nrf2 Signal Pathways using Qingrehuoxue Formula
Fei Xu, Jingtao Zhang, Lingyun Ji, Wenqiang Cui, Jie Cui, Zhao Tang, Ning Sun, Guangming Zhang, Minghao Guo, Baojun Liu, Jingcheng Dong
Abstract
, and MDA while reduced GSH levels. SLC7A11 and GPX4 protein levels were considerably suppressed by QRHXF treatment. Moreover, QRHXF triggered ultrastructural changes in the mitochondria of tumor cells. The levels of p53 and p-GSK-3β were upregulated, whereas that of Nrf2 was downregulated in the groups treated with QRHXF. QRHXF displayed no toxicity in mice. QRHXF activated ferroptosis and apoptosis to suppress NSCLC cell progression via p53 and GSK-3β/Nrf2 signaling pathways.
Topics & Concepts
ApoptosisMMP2VimentinDownregulation and upregulationAngiogenesisMMP9Cancer researchChemistryMatrix metalloproteinaseCell growthEpithelial–mesenchymal transitionBiologyImmunologyImmunohistochemistryBiochemistryGeneFerroptosis and cancer prognosisCancer-related molecular mechanisms researchCancer, Lipids, and Metabolism