Signaling by Type I Interferons in Immune Cells: Disease Consequences
Μαρκέλλα Ζαννίκου, Eleanor N. Fish, Leonidas C. Platanias
Abstract
This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.
Topics & Concepts
Immune systemTumor microenvironmentCancer researchInterferonSignal transductionTumor progressionBiologyCancerImmunologyCancer cellCell biologyGeneticsinterferon and immune responsesCytokine Signaling Pathways and InteractionsCancer-related molecular mechanisms research