Spotlight on AKT: Current Therapeutic Challenges
Ina Landel, Lena Quambusch, Laura Depta, Daniel Rauh
Abstract
The protein kinase B (Akt) exemplifies an important switch of cell death and survival within the PI3K/Akt signaling pathway, which renders Akt a valuable target in diseases such as cancer. Herein, we give a short overview of clinical applications involving Akt, outline promising and innovative approaches to investigate the role of this kinase in diseases, and highlight the current challenges that require thorough investigation to set the groundwork for successful therapeutic strategies.
Topics & Concepts
Protein kinase BPI3K/AKT/mTOR pathwayComputer scienceCancer researchMedicineComputational biologyBioinformaticsSignal transductionBiologyCell biologyPI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia ResearchChronic Myeloid Leukemia Treatments