Single-cell and spatial transcriptome sequencing uncover a platinum-resistant cluster overexpressed TACSTD2 in high-grade serous ovarian cancer
Xiaoyang Han, Yan Gao, Mei Jiang, Zhefeng Li, Jiahao Guo, Yue Li, Junjie Yi, Lisha Hou, Jin Q. Cheng, Lei Feng, Yulan Jin, Xiaoting Zhao, Wentao Yue
Abstract
Our study reveals a platinum-resistant epithelial cell subcluster E0 and its association with TACSTD2 in HGSOC, uncovers new insights and evidence for the platinum resistance mechanism, and provides new ideas and targets for the development of therapeutic strategies against TACSTD2+ epithelial cancer cells.
Topics & Concepts
TranscriptomeOvarian cancerSerous fluidSerous ovarian cancerCluster (spacecraft)Cancer researchComputational biologyBiologyBioinformaticsCancerMedicineGeneComputer scienceGeneticsInternal medicineGene expressionProgramming languageCancer Genomics and DiagnosticsCancer-related molecular mechanisms researchFerroptosis and cancer prognosis