Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy
Lloyd Tanner, Gabriel T. Mashabela, Charles C. Omollo, Timothy J. de Wet, Christopher J. Parkinson, Digby F. Warner, Richard K. Haynes, Lubbe Wiesner
Abstract
This study addresses the development of novel therapeutic compounds for the eventual treatment of drug-resistant tuberculosis. Tuberculosis continues to progress, with cases of Mycobacterium tuberculosis ( M. tuberculosis ) resistance to first-line medications increasing.
Topics & Concepts
IntracellularClofazimineBedaquilinePharmacologyIn vitroMoxifloxacinIn vivoDrugRifampicinMycobacterium tuberculosisTuberculosisIntracellular parasiteChemistryBiologyMedicineImmunologyMicrobiologyCell biologyAntibioticsBiochemistryPathologyBiotechnologyLeprosyTuberculosis Research and EpidemiologyPhenothiazines and Benzothiazines Synthesis and ActivitiesCancer therapeutics and mechanisms