Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy
Jun Sang, Lu Gan, Ming-Feng Zou, Zijun Lin, Run‐Zhu Fan, Jia-Luo Huang, Wei Li, Gui‐Hua Tang, Sheng Yin
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayProtein kinase BPTENEverolimusCancer researchTemsirolimusSignal transductionMedicineDual roleApoptosisPharmacologyChemistryInternal medicineDiscovery and development of mTOR inhibitorsBiochemistryCombinatorial chemistryPI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and ApplicationsAutophagy in Disease and Therapy