Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
James Millard, Stephanie Rimmer, Camus Nimmo, Max R. O’Donnell
Abstract
New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance. We report a case of bedaquiline and delamanid resistance in a 55-year-old woman in South Africa with extensively drug-resistant tuberculosis and known HIV.
Topics & Concepts
BedaquilineDrug resistanceMedicineIntensive care medicineDrugExtensively drug-resistant tuberculosisDrug toleranceTuberculosisVirologyMultiple drug resistanceMicrobiologyPharmacologyMycobacterium tuberculosisBiologyPathologyTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatmentInfectious Diseases and Tuberculosis