Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice
Jie Lü, Yuwei He, Lingling Cui, Xiaoming Xing, Zhen Liu, Xinde Li, Hui Zhang, Hailong Li, Wenyan Sun, Aichang Ji, Yao Wang, Huiyong Yin, Changgui Li
Abstract
-KO (STZ-KO) mice. Shared differentially expressed genes of HU primacy revealed Stk17β is a possible target gene in HU-related β-cell death. Together, this study suggests that HU accelerates but does not cause diabetes by inhibiting islet β-cell survival.
Topics & Concepts
Internal medicineEndocrinologyStreptozotocinDiabetes mellitusHyperuricemiaMedicineImpaired glucose toleranceInsulin resistanceUric acidGout, Hyperuricemia, Uric AcidAlcohol Consumption and Health EffectsDiet, Metabolism, and Disease