Palladium-catalyzed double-carbonylative cyclization of propargyl alcohols and aryl triflates to expedite construction of 4-aroyl-furan-2(5<i>H</i>)-ones
Jun Ying, Zhengjie Le, Xiao‐Feng Wu
Abstract
A palladium-catalyzed double-carbonylative cyclization of propargyl alcohols and aryl triflates has been developed. Various 4-aroyl-furan-2(5<italic>H</italic>)-one scaffolds were produced in good yields with Cr(CO)<sub>6</sub> as the CO source.
Topics & Concepts
ChemistryPropargylFuranPalladiumArylCatalysisMedicinal chemistryOrganic chemistryCombinatorial chemistryAlkylCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods