Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis
Chao Sun, Wei Liu, Zhiqiang Lu, Yan Li, Shengnan Liu, Zhili Tang, Ying Yan, Zhiyang Li, Hua Feng, Duo Zhang, Yun Liu, Zhong‐Ze Fang, Changtao Jiang, Qiurong Ding, Jingjing Jiang, Hao Ying
Abstract
TH-responsive hepatic miR-378 is capable of modulating serum cholesterol levels by regulating both the classic and alternative BA synthetic pathways. Our study not only identifies a previously undescribed role of hepatic miR-378 but also provides new cholesterol-lowering approaches.
Topics & Concepts
Bile acidChemistryCholesterolInternal medicineEndocrinologyMedicineBiochemistryDrug Transport and Resistance MechanismsLiver Disease Diagnosis and TreatmentCholesterol and Lipid Metabolism