DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
Michelle Swift, Kate Beishline, Samuel Flashner, Jane Azizkhan‐Clifford
Abstract
cells to poly (ADP-ribose) polymerase (PARP) inhibition similar to BRCA1 deficiency. These data demonstrate how Sp1 integrates the cell cycle and DSB repair pathway choice to favor NHEJ.
Topics & Concepts
Homologous recombinationCell cycleCell biologyPoly ADP ribose polymeraseTranscription factorBiologyPhosphorylationDNA repairMolecular biologyPolymeraseGeneticsCellDNAGeneDNA Repair MechanismsCRISPR and Genetic EngineeringPARP inhibition in cancer therapy