Intramitochondrial co-assembly between ATP and nucleopeptides induces cancer cell apoptosis
Huyeon Choi, Gaeun Park, Eun-Hye Shin, Seon Woo Shin, Batakrishna Jana, Seongeon Jin, Sangpil Kim, Huaimin Wang, Sang Kyu Kwak, Bing Xu, Ja‐Hyoung Ryu
Abstract
). To improve anticancer efficacy, the small-sized MNP/ADP complex formed large assemblies with ATP inside cancer cell mitochondria. ATP sequestration and formation of large assemblies of the MNP/ADP-ATP complex inside mitochondria caused physical stress by large structures and metabolic disorders in cancer cells, leading to apoptosis. This work illustrates a facile approach to developing cancer therapeutics that relies on molecular assemblies.
Topics & Concepts
ApoptosisCell biologyCancer cellCellMitochondrionChemistryCancerBiochemistryBiologyGeneticsATP Synthase and ATPases ResearchRNA modifications and cancerMitochondrial Function and Pathology