Diamine-mediated N<sup>2</sup>-selective β-selenoalkylation of triazoles with alkenes
Li-Li Zhu, Lifang Tian, Bin Cai, Guanglu Liu, Hui Zhang, Yahui Wang
Abstract
A N2-selective β-selenoalkylation of 1,2,3-triazoles with alkenes mediated by diamines has been developed. The reaction proceeds presumably via the interaction of diamines with both the triazole moiety and selenium/alkene complex to construct a U-shaped reaction intermediate. This activation mode will block the N1 position on triazoles and thus favor the N2-selective selenoamination. This stereospecific anti-addition method enables an efficient N2-selective β-selenoalkylation of 1,2,3-triazoles under mild and open-air conditions and might find applications in the synthesis of biologically active molecules.
Topics & Concepts
DiamineChemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCarbon dioxide utilization in catalysis