Litcius/Paper detail

Lewis acid-catalyzed regioselective C–H carboxamidation of indolizines with dioxazolones<i>via</i>an acyl nitrene type rearrangement

Dan Song, Changfeng Huang, Peishi Liang, Baofu Zhu, Xiang Liu, Hua Cao

2021Organic Chemistry Frontiers37 citationsDOI

Abstract

An efficient, direct, and novel Lewis acid-catalyzed regioselective C–H carboxamidation of indolizines with dioxazolones<italic>via</italic>an acyl nitrene type rearrangement under metal-free conditions has been documented.

Topics & Concepts

NitreneRegioselectivityChemistryLewis acids and basesCatalysisMedicinal chemistryStereochemistryOrganic chemistrySynthesis and Reactivity of HeterocyclesCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms