Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation
Yuanxin Guo, Xiaohong Tracey Gan, Houfeng Zhou, Hongjing Zhou, Shiyun Pu, Long Xia, Changyu Ren, Tao Feng, Hongmei Tang
Topics & Concepts
NeuroprotectionNeuroinflammationOxidative stressInflammasomeHippocampal formationMorris water navigation taskOpen fieldMicrogliaMedicineBehavioural despair testHippocampusPharmacologyNeuroscienceInternal medicineEndocrinologyReceptorInflammationPsychologyAntidepressantTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol