Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France
Grégory Quéromès, Grégory Destras, Antonin Bal, Hadrien Regue, Gwendolyne Burfin, Solenne Brun, Rémi Fanget, Florence Morfin, Martine Valette, Sophie Trouillet‐Assant, Bruno Lina, Émilie Frobert, Laurence Josset
Abstract
, for which high plasma levels have been associated with severe COVID-19. Our findings emphasize the need to monitor the occurrence of ORF6 deletions and assess their impact on the host immune response.
Topics & Concepts
BiologyVirologyImmune systemGeneOpen reading frameTransmission (telecommunications)MedicineImmunologyGeneticsPeptide sequenceEngineeringElectrical engineeringSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyAnimal Virus Infections Studies