LiN(SiMe<sub>3</sub>)<sub>2</sub>/KO<sup>t</sup>Bu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles
Peng Ma, Yuhang Wang, Jianhui Wang, Ning Ma
Abstract
A convenient method is proposed for the synthesis of isoquinolone derivatives from 2-methylaryl aldehydes and nitriles through LiN(SiMe 3 ) 2 /KO t Bu-promoted formal [4 + 2] cycloaddition reaction, featuring high atomic economy, good functional group tolerance, and easy operation. It enables the efficient formation of new C–C and C–N bonds toward isoquinolones without using preactivated amides.
Topics & Concepts
ChemistryCycloadditionNitrileCombinatorial chemistryFunctional groupMedicinal chemistryReaction conditionsOrganic chemistryStereochemistryCatalysisPolymerAdvanced Synthetic Organic ChemistryCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis