Design and synthesis of novel pyridopyrimidine derivatives with anchoring non-coplanar aromatic extensions of EGFR inhibitory activity
Amal A.M. Eissa, Kholoud F.M. Aljamal, Hany S. Ibrahim, Heba Abdelrasheed Allam
Topics & Concepts
ChemistryGefitinibCytotoxicityEGFR inhibitorsStereochemistryDocking (animal)IsothiocyanateCell cycle checkpointApoptosisIn vitroIC50Cell cultureStructure–activity relationshipCell cycleEpidermal growth factor receptorBiochemistryReceptorMedicineBiologyNursingGeneticsQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsSynthesis and biological activity