LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling
JingHong Wan, Emmanuel Weiss, Sanae Ben Mkaddem, Morgane Mabire, Pierre‐Marie Choinier, Olivia Picq, Tristan Thibault-Sogorb, Pushpa Hegde, Dorsa Pishvaie, Marcelle Bens, Linda Broer, Hélène Gilgenkrantz, Richard Moreau, Loredana Saveanu, Patrice Codogno, Renato C. Monteiro, Sophie Lotersztajn
Abstract
fragments, or with intravenous immunoglobulin (IVIg). These data suggest the existence of an ITAMi-mediated mechanism by which LAP might protect against inflammation. Sustaining LAP may open therapeutic perspectives for patients with chronic liver disease.
Topics & Concepts
PhagocytosisInflammationFibrosisSignal transductionLiver fibrosisInhibitory postsynaptic potentialImmunologyCell biologyBiologyMedicineNeurosciencePathologyPhagocytosis and Immune RegulationImmune Cell Function and InteractionAutophagy in Disease and Therapy