Kefir peptides ameliorate osteoporosis in AKR1A1 knockout mice with vitamin C deficiency by promoting osteoblastogenesis and inhibiting osteoclastogenesis
Gary Ro‐Lin Chang, Wei‐Yu Lin, Hueng‐Chuen Fan, Min‐Yu Tu, Yu-Hsien Liu, Chih‐Ching Yen, Abdulkadir Cidem, Wei Chen, Chuan‐Mu Chen
Abstract
mice and also unveil the dual effects of KPs in osteogenic promotion and osteoclastic inhibition. This study supports the use of KPs as nutritional supplements for the prevention of osteoporosis.
Topics & Concepts
EndocrinologyInternal medicineOsteoblastOsteoclastChemistryRANKLBone resorptionProinflammatory cytokineBone remodelingOsteoporosisBone marrowBone mineralKnockout mouseMedicineInflammationBiochemistryReceptorIn vitroActivator (genetics)Aldose Reductase and TaurineVitamin C and Antioxidants ResearchFluoride Effects and Removal