Sulfoxide Reductases and Applications in Biocatalytic Preparation of Chiral Sulfoxides: A Mini-Review
Tao Peng, Xiaoling Cheng, Yong‐Zheng Chen, Jiawei Yang
Abstract
Chiral sulfoxides are valuable organosulfur compounds that have been widely used in medicinal and organic synthesis. Biocatalytic approaches for preparing chiral sulfoxides were developed in the past few years, mainly through asymmetric oxidation of prochiral sulfides. Recently, the application of sulfoxide reductase to prepare chiral sulfoxides through kinetic resolution has emerged as a new method, exhibiting extraordinary catalytic properties. This article reviews the chemical and biological functions of these sulfoxide reductases and highlights their applications in chiral sulfoxide preparation.
Topics & Concepts
SulfoxideOrganosulfur compoundsKinetic resolutionBiocatalysisChemistryOrganic chemistryEnantioselective synthesisCatalysisCombinatorial chemistrySulfurReaction mechanismChemical Synthesis and ReactionsEnzyme Catalysis and ImmobilizationSulfur-Based Synthesis Techniques