Elucidating the Antiviral Mechanism of Different MARCH Factors
Supawadee Umthong, Brian Lynch, Uddhav Timilsina, Brandon Waxman, Emily B. Ivey, Spyridon Stavrou
Abstract
This study examines the mechanism utilized by different MARCH proteins to restrict retrovirus infection. MARCH proteins block the incorporation of envelope glycoproteins to the budding virions. In this report, by comparing the human and mouse MARCH genes and using murine leukemia virus (MLV) and HIV-1, we identify differences in the mechanism of restriction among MARCH proteins. Furthermore, we perform a comprehensive analysis on a number of envelope glycoproteins and show that MARCH proteins have broad antiviral functions.
Topics & Concepts
Mechanism (biology)Computational biologyVirologyBiologyPhilosophyEpistemologyinterferon and immune responsesViral Infections and Immunology ResearchImmune Cell Function and Interaction