Pregnancy associated breast cancer
Heather Macdonald
Abstract
Pregnancy associated breast cancer (PABC) defined as breast cancer occurring during pregnancy or within the first 1-2 years postpartum. Delay in diagnosis is common. Treatment is timed around gestational age. Surgery and chemotherapy are considered safe after the first trimester. Radiation, anti-her-2, and endocrine therapy are delayed until after delivery due to adverse fetal effects. Iatrogenic prematurity likely causes most long-term fetal sequelae. Multi-disciplinary care and social support are critical for patients and families with PABC.
Topics & Concepts
MedicinePregnancyBreast cancerObstetricsRadiation therapyFirst trimesterCancerAdverse effectGestationEndocrine systemFetusChemotherapyGynecologySurgeryInternal medicineHormoneGeneticsBiologyCancer Risks and FactorsChildhood Cancer Survivors' Quality of LifeBirth, Development, and Health