First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase I dose exploration
Jordi Rodón, Hans Prenen, Adrian G. Sacher, Miguel A. Villalona‐Calero, Nicolas Penel, Aya El Helali, Sylvie Rottey, Noboru Yamamoto, François Ghiringhelli, Matthias Goebeler, Toshihiko Doi, Sophie Postel‐Vinay, C-C Lin, Liu C, C-H Chuang, Kiana Keyvanjah, Torsten Eggert, Bert H. O’Neil
Topics & Concepts
Protein arginine methyltransferase 5MedicineMaximum tolerated doseCancer researchArgininePharmacologyMethyltransferaseBiochemistryPharmacokineticsAmino acidBiologyMethylationGeneCancer-related gene regulationVirus-based gene therapy researchPolyamine Metabolism and Applications