5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis
Pingping Zhu, Tiankun Lu, Zhenzhen Chen, Benyu Liu, Dongdong Fan, Chong Li, Jiayi Wu, Luyun He, Xiaoxiao Zhu, Ying Du, Yong Tian, Zusen Fan
Topics & Concepts
Colorectal cancerWnt signaling pathwayCancer researchSerotonergicCarcinogenesisBiologyStem cellCancer stem cellCell biologyMetastasisTPH2Mouse model of colorectal and intestinal cancerSignal transductionCancerReceptorSerotoninGeneticsGastrointestinal motility and disordersCancer Cells and MetastasisHelicobacter pylori-related gastroenterology studies