One-pot Synthesize of Phenyl Phenanthro Imidazole Derivatives Catalyzed by Lewis Acid in the Presence of Ammonium Acetate
Elham Haddazadeh, Mohammad Kazem Mohammadi
Abstract
Tri substituted imidazole derivatives were synthesized with the combinations of phenanthroquinone, benzealdehyde derivatives at the presence of ammonium acetate that catalyzed by Lewis acid. In all reactions, polar solvent was used and the reactions were carried out under the reflux conditions. The structure of all compounds was confirmed using the IR and 1HNMR. This method revealed several advantages including, excellent yields, simplicity of operation and easy separation. The results showed that, products formed in high yields and low reaction times. Also, the metal atom of Lewis acid catalyst increased the reactivity of substrate and the reaction time.
Topics & Concepts
Lewis acids and basesImidazoleCatalysisChemistryAmmonium acetateReactivity (psychology)Lewis acid catalysisOrganic chemistrySubstrate (aquarium)High-performance liquid chromatographyAlternative medicineMedicineGeologyOceanographyPathologyMulticomponent Synthesis of HeterocyclesSynthesis and biological activityBioactive Compounds and Antitumor Agents