Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
Mariana Galvão Ferrarini, Líndice Mitie Nisimura, Richard M. B. M. Girard, Mayke Bezerra Alencar, Mariana Sayuri Ishikawa Fragoso, Carlla Assis Araújo-Silva, Alan de Almeida Veiga, Ana Paula Ressetti Abud, Sheila Cristina Nardelli, Rossiane C. Vommaro, Ariel Mariano Silber, Marie France-Sagot, Andréa Rodrigues Ávila
Abstract
, followed by an unbalanced mitochondrial activity, in a manner similar to what was previously observed in cancer cells. Thus, we propose the conserved kinases as potential regulators of pyruvate metabolism and interesting targets for new therapies.
Topics & Concepts
Pyruvate dehydrogenase complexPyruvate dehydrogenase kinaseKinaseToxoplasma gondiiBiologyMitochondrionCitric acid cyclePyruvate kinaseCell biologyBiochemistryMetabolismEnzymeGlycolysisImmunologyAntibodyCancer, Hypoxia, and MetabolismPeroxisome Proliferator-Activated ReceptorsAutophagy in Disease and Therapy