3D printed fibroblast-loaded hydrogel for scleral remodeling to prevent the progression of myopia
Jingwen Hui, Xiongfeng Nie, P. Wei, Jie Deng, Yuanzhe Kang, Kexin Tang, Guoge Han, Ling Wang, Wenguang Liu, Quanhong Han
Abstract
incubation, and could normally secrete collagen type I. Eventually, both the hydrogel and fibroblast-loaded hydrogel demonstrated an effective shortening of the myopic eye axis length in a guinea pig model of visual deprivation over three weeks after implantation, and the sclera thickness of myopic guinea pigs became significantly thicker after 4 weeks, verifying the success of sclera remodeling and showing that myopic progression was effectively controlled. In particular, the fibroblast-loaded hydrogel demonstrated the best therapeutic effect through the synergistic effect of cell therapy and PSR surgery.
Topics & Concepts
Self-healing hydrogelsFibroblast3D bioprintingBiomedical engineeringDermal fibroblastMaterials science3d printedTissue engineeringChemistryMedicinePolymer chemistryBiochemistryIn vitroCorneal surgery and disordersOphthalmology and Visual Impairment StudiesOcular Surface and Contact Lens