Iridium‐Catalyzed Carbenoid Insertion of Sulfoxonium Ylides for Synthesis of Quinoxalines and β‐Keto Thioethers in Water
Yingying Xu, Xin Huang, Guanghui Lv, Ruizhi Lai, Songyang Lv, Jianglian Li, Li Hai, Yong Wu
Abstract
Sulfoxonium ylides as safe carbene precursors are described for iridium‐catalyzed carbene insertions and annulation, providing a facile and green approach to access a variety of quinoxaline derivatives in water. This water‐mediated method also allows the preparation of β‐keto thioethers under mild condition.
Topics & Concepts
CarbeneChemistryIridiumCarbenoidAnnulationQuinoxalineCatalysisCombinatorial chemistryOrganic chemistryMedicinal chemistryRhodiumSynthesis and Biological EvaluationCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods